改性防护蜡对轮胎胎侧胶性能的影响

研究改性防护蜡对轮胎胎侧胶性能的影响。结果表明,与传统防护蜡相比,改性防护蜡异构烷烃质量分数较小,结晶尺寸小且致密程度高。改性防护蜡可在不影响胎侧胶硫化特性和物理性能的前提下,大幅提高胎侧胶抗喷霜性能,保证轮胎表面不受臭氧侵蚀,在防止裂纹产生的同时明显改善成品轮胎外观。     

Neutrophils in Tuberculosis: Cell Biology,Cellular Networking and Multitasking in Host Defense

Neutrophils readily infiltrate infection foci, phagocytose and usually destroy microbes. In tuberculosis (TB), a chronic pulmonary infection caused by Mycobacterium tuberculosis (Mtb), neutrophils harbor bacilli, are abundant in tissue lesions, and their abundances in blood correlate with poor disease outcomes in patients. The biology of these innate immune cells in TB is complex. Neutrophils have been assigned host-beneficial as well as deleterious roles. The short lifespan of neutrophils purified from blood poses challenges to cell biology studies, leaving intracellular biological processes and the precise consequences of Mtb–neutrophil interactions ill-defined. The phenotypic heterogeneity of neutrophils, and their propensity to engage in cellular cross-talk and to exert various functions during homeostasis and disease, have recently been reported, and such observations are newly emerging in TB. Here, we review the interactions of neutrophils with Mtb, including subcellular events and cell fate upon infection, and summarize the cross-talks between neutrophils and lung-residing and -recruited cells. We highlight the roles of neutrophils in TB pathophysiology, discussing recent findings from distinct models of pulmonary TB, and emphasize technical advances that could facilitate the discovery of novel neutrophil-related disease mechanisms and enrich our knowledge of TB pathogenesis.     

Supramolecular Assembly of Aminoethylene‐Lipopeptide PMO Conjugates into RNA Splice‐Switching Nanomicelles

Phosphorodiamidate morpholino oligomers (PMOs) are oligonucleotide analogs that can be used for therapeutic modulation of pre‐mRNA splicing. Similar to other classes of nucleic acid‐based therapeutics, PMOs require delivery systems for efficient transport to the intracellular target sites. Here, artificial peptides based on the oligo(ethylenamino) acid succinyl‐tetraethylenpentamine (Stp), hydrophobic modifications, and an azide group are presented, which are used for strain‐promoted azide‐alkyne cycloaddition conjugation with splice‐switching PMOs. By systematically varying the lead structure and formulation, it is determined that the type of contained fatty acid and supramolecular assembly have a critical impact on the delivery efficacy. A compound containing linolenic acid with three cis double bonds exhibits the highest splice‐switching activity and significantly increases functional protein expression in pLuc/705 reporter cells in vitro and after local administration in vivo. Structural and mechanistic studies reveal that the lipopeptide PMO conjugates form nanoparticles, which accelerate cellular uptake and that the content of unsaturated fatty acids enhances endosomal escape. In an in vitro Duchenne muscular dystrophy exon skipping model using H2K‐mdx52 dystrophic skeletal myotubes, the highly potent PMO conjugates mediate significant splice‐switching at very low nanomolar concentrations. The presented aminoethylene‐lipopeptides are thus a promising platform for the generation of PMO‐therapeutics with a favorable activity/toxicity profile.     

Removal of nitrates from groundwater through the use of artificial wetlands

Intensive fertilizer use has led to nitrate contamination of groundwater in many areas. This article examines the possibility of removing nitrates through the construction of artificial wetlands. A pilot study conducted in Denmark has found that the method is effective and economical, at least for small waterworks, though further treatment is necessary before an acceptable microbiological water quality is attained.     

用化学腐蚀制备多孔硅太阳电池减反射膜的研究

采用HF HNO3溶液化学腐蚀 ,在硅片上制备减反射效果优良的多孔硅太阳电池减反射膜 ,借助原子力显微镜 (AFM)和X光电子谱 (XPS)对其表面形貌和成分进行观察 ,发现该膜与电化学阳极腐蚀得到的多孔硅具有相似性 ,其主要成分为非化学配比的硅的氧化物SiOx(X <2 )。采用带积分球的光度分光计 ,测得形成多孔硅减反射膜后 ,硅片表面反射率大大下降 ,,在波长 330～ 80 0nm范围反射率只有 1 5～ 2 9%。研究指出这种强减反射作用 ,与多孔硅具有合适的折射率及其多孔特性的光陷阱作用有关     

Prenatal diagnosis of a highly undifferentiated brain tumour--a case report and review of the literature

Intracranial tumours, often presenting with progressive hydrocephalus, are rare congenital diseases accounting for 0.5-1.5 per cent of all cases of brain tumours diagnosed during childhood. The differential diagnosis includes vascular malformations, infarctions, and haemorrhages. Sonographic signs suggestive of glioblastoma, teratoma, and astrocytoma do not establish the histological diagnosis, however. We report a case of an undifferentiated fetal glioma detected at 29 weeks' gestation. The diagnosis of an undifferentiated brain tumour was suspected by sonography because of the lack of normal brain structures in conjunction with a diffuse echogenic central lesion and an external hydrocephalus. Because of the very poor prognosis, we induced labour by intravaginal and intravenous administration of prostaglandin E2 and achieved the vaginal delivery of a stillborn child whose head circumference corresponded to 38 weeks of pregnancy. Histological and immunochemical features of this undifferentiated congenital glioma (glioblastoma) are presented.     

西北江三角洲来水来沙的非线性分形特征

根据西、北江干流高要、石角及西北江三角洲网河区顶点马口、三水四个水文站的流量和含沙量资料 ,应用非线性分形原理的R S方法 ,计算西北江干流及西北江网河区顶点四个水文站的流量、含沙量的赫斯特数H和分形维数D ;探讨西、北江干流来水来沙的分形特征及西北江三角洲的分水分沙规律。结果表明 ,流量的分维数略大于含沙量的分维数 ,三水站流量及含沙量的分维数与其上游的石角站流量、含沙量的分维数相差较大 ,与思贤的分水分沙造成西北江的水沙交换有关     

钕电解阳极过电位的测定

用慢扫描示波法测定了钕电解的阳极过电位 .考察了温度、阳极电流密度、Nd2 O3添加量、电解质组成等因素对阳极过电位的影响 ,探讨了降低阳极过电位的可能途径 .结果表明 ,阳极过电位随阳极电流密度的增加而增大 ,随温度的升高而减小 ,一定范围内 ,阳极过电位与阳极电流密度的对数呈线性关系 ,满足塔菲尔方程 ;电解质中LiF和Nd2 O3浓度增加 ,阳极过电位降低 ;适当控制阳极电流密度、升高温度、增加电解质中LiF和Nd2 O3的浓度并尽可能减小极间距 ,均有利于降低阳极过电位     

基于VXI总线的机载火控系统自动测试仪的设计

目的　对作战飞机火控系统的故障检测 ,传统的方法是使用多种检测仪器对机载火控设备进行性能检查 ,不仅技术含量低 ,也给飞机转场后技术阵地的转移带来不便 ,不能满足现代战争的需要 ,为提高战机的作战效能和快速反应的能力 ,研制了机载火控系统自动测试仪 .方法　采用 VXI总线技术、合理的硬件配置和在 Lab Windows/CVI环境下的软件模块化设计方案 .结果　在实际应用中取得了良好效果 ,为技术人员进行机载火控系统的性能及故障检测提供了便利 .结论　该测试仪具有测试结果准确 ,自动化程度高 ,工作稳定可靠 ,操作简便 ,易于转移和维护等优点 ,并具有较高的抗干扰能力 ,不仅适用与内场 ,还可用于在外场对机载火控系统进行原位检测     

Role Models for Radical Innovations in Times of Open Innovation

In this paper, we study the influence of innovator roles in highly innovative ventures. In order to obtain a differentiated picture we take into account the degree of innovativeness as a moderating variable. To test our hypotheses we use a sample of 146 highly innovative new product development projects. We choose a rigorous sampling design and apply state‐of‐the‐art measures for the degree of innovativeness. Furthermore, we apply multi‐trait‐multi‐method methodology (MTMM) to enhance the validity of our study. The results show that innovator roles have a strong influence on innovation success but these influences are positively and negatively moderated by innovativeness. The moderating influences depend on the type of innovativeness. Remarkably, with increasing technological innovativeness innovator roles which create inter‐organizational links with the outside world appear to be more important than intra‐organizational linker roles, and support from high‐ranked organizational members turns out to have a significant negative effect on project success with higher degrees of technological innovativeness. Possible explanations for these findings are discussed and consequences for innovation research and innovation management are shown.